Oleacein – Another Helpful Polyphenol
Because of its distinctive characteristics, scientific interest in oleacein only began relatively recently. The compound was first discovered and isolated in olive leaves, and its presence and importance in extra virgin olive oil (EVOO) were not immediately understood. Researchers now recognize oleacein as not only one of the most abundant phenolic compounds in virgin olive oils but also among the most chemically active. In contrast, hydroxytyrosol—a well-studied phenolic—exists in olive oil only in small amounts.
“Oleacein is an ester of hydroxytyrosol, but unlike hydroxytyrosol, which dissolves only in water, oleacein is amphiphilic, meaning it can dissolve in both water and fats,” explained one of the researchers.
Oleacein’s Potential Health Impact
This dual solubility may help explain oleacein’s broad activity within the human body, enabling it to interact with both lipid and aqueous systems. Beyond that, it exhibits strong anti-inflammatory effects, though through different mechanisms than better-known EVOO phenolics like oleocanthal. Importantly, oleacein also acts as a metabolite—it appears in the body as a byproduct after digestion of phenolic esters, including itself.
As Fátima Paiva-Martins noted, “Hydroxytyrosol is highly water-soluble, so very little remains in the oil itself. What we detect in higher concentrations are its esters, such as oleacein, which then break down into hydroxytyrosol during digestion.”
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